While classic Nintendo series games show control development to take advantage of whatever control setup is in it's launch gen (see Zelda with motion controls, etc.) So I have no doubt the new Zelda will be fine.
However, the real question becomes what other games (Nintendo or no) would benefit from the home to portable hybrid model.
I can give a short list:
Monster Hunter – This series made the switch back and forth from the Wii U to 3DS with very little issues. I can't be the only person who would dearly love a higher rez take on the game that I can take on the go or play at home online with friends?
Rocket League – I think this title would fit perfect in party play with the micro controller. Add in some online play and you should be good to go.
4 Swords type game. I'd love a multiplayer Zelda like title for the Switch. I think a 2 player Zelda or Zelda-like would work out with the way the controllers sync up.
Disgaea – Because why not.
Advanced Wars HD – Something like this would be a god send. I'd get nicer graphics, Advanced Wars type turn based battles, on the go, at home play. Best of both worlds.
Any you can think of?